Defender Michael Raynes' aerial presence was often used in attacking situations by boss Keith Curle, the uggs clearance defender himself heading over a chance midway through the first half.
Argyle uggs outlet tightened up Macy's UGG Boots Black Friday and made it a more difficult contest for the Blues, but they eventually found a way through when Raynes challenged for Grainger's delivery, and Lambe did the rest by hammering low past keeper Luke McCormick.
The summer signing almost added another moments later, heading just wide after beating McCormick to a high ball, with the dangerous Nicky Adams also going close before the break.
Plymouth changed systems at the break, changing their three at the back formation to 4 3 3, and clear cut chances were few for both sides as a tight contest unfolded.
Lambe almost set up Shaun Miller on the break, while former Blues man Jake Jervis, on as cheap ugg boots on sale sub, headed over a good chance for Derek Adams' side.
Carlisle then had Grainger to thank for preserving victory, the Cumbrian throwing himself in the way of Gary Miller's 83rd minute shot after Mark Gillespie had parried a Jervis attempt.
Jabo Ibehre and Jamie Devitt returned as second half subs as United saw the victory home.