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Is it true that combining sedative-hypnotics with alcohol is especially dangerous? Yes. Taken together, alcohol and sedative-hypnotics can kill. The use of barbiturates and other sedative-hypnotics with other drugs that slow down the body, such as alcohol, multiplies their effects and greatly increases the risk of death. Overdose deaths can occur when barbiturates and alcohol are used together, either deliberately or accidentally. Friday, December 17th, 2010 REFERENCES AIDS/96701492. Anonymous. Salk therapy Principe de meilleure pratique (No. 10)