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The FDA considered data from both the NIAAA-supported studies and the Dupont Merck study in approving naltrexone as an adjunct to conventional treatments. GRAND ROUND [0022] For ease of explanation, the ensuing discussion will focus on current pulsing, in which a current source applies a current across one or more electrode pairs in accordance with the desired pulse profile; it should be understood, however, that the same principles apply to voltage pulsing. In monophasic pulsing, illustrated in Fig. IA, a constant current is passed for a period of time (generally on the order of tens to hundreds of microseconds), and then the external stimulator circuit is open-circuited (i.e. effectively removed electrically from the electrodes) until the next pulse. In biphasic pulsing, a constant current is passed in one direction, then the direction of current is reversed, and then the circuit is open-circuited until the next pulse. In biphasic pulsing the first phase, or stimulating phase, is used to elicit the desired physiological effect such as initiation of an action potential, and the second phase, or reversal phase, is used to reverse electrochemical processes occurring during the stimulating pulse. The reversal phase helps reverse conditions that can damage tissue and the metal electrodes. For this reason, monophasic pulsing is most efficacious for stimulation, but is not as safe (in terms of avoiding tissue damage) as biphasic pulsing; see D.R. Merrill et al. J Neurosci. Meth. 141:171-198 (2005). Accordingly, biphasic pulsing is preferred for the present invention, although monophasic pulsing may be useful in some applications. Whew! I don't know about that Doctor's advice. Just reading all this makes my head spin. My understanding of Antibuse was that it was supposed to take all the thought of drinking OUT of the equation to free your mind for other stuff. But it sounds like with all the shimmying in your mind regarding what to take, when, how much, fear about getting sick, etc etc is just feeding the obsession about alcohol. Suddenly one is one's own chemist - I would be too lazy to mess with that and I was never great at Chemistry. That's too much work for me.  

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